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バイオサイトジェンのビジョン
バイオサイトジェンは、創造的かつ規模化された抗体医薬品開発プラットフォーム「RenMice HiTS Platform」を基に革新的な抗体医薬品開発を続けていきます。
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研究領域
新薬研究開発の全過程をプラットフォーム化して、バイオサイトジェンは免疫療法, 自己免疫疾患, 代謝疾患および感染病などの疾病領域について様々な研究開発を行っています。様々な疾患に対して高い効果と安全性を持つ抗体医薬品を開発·普及することに力を注いでいます。
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CTLA-4
OX40
CD40
4-1BB
抗感染
バイオサイトジェンの技術
バイオサイトジェンが独自開発したRenMiceプラットフォームを基に、弊社はGPCR創薬研究開発プラットフォーム、TCR技術プラットフォーム、二重特異性抗体技術プラットフォームなど、抗体医薬品ディスカバリープラットフォームを持続的に構築し、規模化された抗体医薬品の開発を加速しています。
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研究提携
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Beijing, China and Heidelberg, Germany, June 3, 2022 -- Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen") today announced 3 poster presentations for two novel fully human antibody platforms and one bispecific ADC asset at Antibody Engineering & Therapeutics Europe (AET-EU) 2022 taking place on June 7-9, 2022 in Amsterdam and online. Antibody BD & licensing team from Biocytogen Europe Innovation Center (BEIC)  will be on-site to present posters and booth (#3). Introducing Biocytogen’s RenMice™ HiTS (Hyperimmune Target Specific) Platform, also called Project Integrum, for identification of new therapeutic antibodies, our BEIC team will present current progress of this platform that features the knocking out of 1000+ potentially druggable targets from fully human antibody RenMice™ (RenMab™ and RenLite®) for the purpose of generating fully human antibodies covering diverse epitopes with high affinity and specificity. Combining with downstream high-throughput in vivo efficacy screening ability, Project Integrum offers a streamlined solution to develop antibodies that recognize novel and challenging targets. Our team will also present Biocytogen’s novel TCR-mimic platform for discovering fully human antibodies against intracellular targets. The platform utilizes HLA-expressing fully human antibody mice (HLA/RenMab mice) to generate antibodies binding intracellular tumor-associated antigens in the context of HLA when immunized with MHC-antigen-peptide complexes. Subsequently, Biocytogen’s high-throughput antibody screening platform enables a swift identification of TCR-mimic antibodies with higher specificity and affinity than endogenous TCRs derived from patients. Currently, antibody hits for multiple intracellular targets are undergoing in vitro and in vivo characterization. Fully human antibody sequences obtained from the TCR-mimic platform can empower the development of T cell engagers, bispecific/multispecific antibodies, and CAR-T therapies. A preclinical candidate YH012 will also be introduced. It is a HER2 x TROP2 bispecific ADC generated from our proprietary bsADC platform, taking advantages of our common light chain RenLite® mice to acquire bispecific antibodies with high affinity and specificity as well as good stability for downstream drug conjugation. In vivo drug efficacy data shows potent anti-tumor activity. About Biocytogen Biocytogen Pharmaceuticals (Beijing) Co., Ltd. is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMabTM /RenLite® mice platforms for fully human monoclonal and bispecific antibody development, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop antibody drugs for more than 1000 targets, known as Project Integrum, and has entered ongoing collaborations with dozens of partners worldwide to produce a variety of first-in-class and/or best-in-class antibody drugs. The company's pipeline includes 12 core products, among which two products are in phase II multi-regional clinical trials and two products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. For more information, please visit en.biocytogen.com.cn. For more information, please contact: Antibody assets: Vivian Tian, PhD, MBA Email: BD-Licensing@biocytogen.com Office: +86 010-56967680 Media Zimeng Zhang, PhD Email: pr@bbctg.com.cn Office: +86 010-56967680
2022.06.03
Beijing, China, May 24, 2022 /PRNewswire/ -- Eucure Biopharma, a wholly owned subsidiary of Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen"), today announced that it will present two posters at the 2022 ASCO Annual Meeting, taking place in Chicago, IL and virtually from June 3-7, 2022. The posters describe updates from two phase I clinical studies in Australia for internally developed monoclonal antibodies (mAbs) YH003 (anti-CD40, abstract # 2603) and YH001 (anti-CTLA-4, abstract # 2602). Both YH003 and YH001 demonstrate favorable safety and tolerability profiles and preliminary efficacy when administered in combination with anti-PD-1 mAb to patients with advanced solid tumors. The details of the presentations are as follows: Title: A phase I open-label, dose escalation of YH003, an anti-CD40 monoclonal antibody, in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors. Corresponding author: Dr. Jermaine Coward Trial: NCT04481009 Abstract number: 2603 Session: Poster Session 3: Developmental Therapeutics—Immunotherapy Title: A first-in-human phase I dose escalation of YH001, an anti-CTLA-4 monoclonal antibody (mAb), in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors. Corresponding author: Dr. Vinod Ganju Trial: NCT04357756 Abstract number: 2602 Session: Poster Session 3: Developmental Therapeutics—Immunotherapy Both posters will be presented in-person on Sunday, June 5 from 8:00 AM–11:00 AM CT. About YH003 YH003 is a humanized IgG2 agonistic CD40 antibody. Whether used as a single agent or in combination with anti-PD-1 mAb drugs, YH003 demonstrated strong anti-tumor effects against multiple tumor models in Biocytogen’s humanized CD40 mice, without exhibiting hepatotoxicity or other toxicities. Pharmacodynamic studies in mice indicate that YH003 significantly increased the infiltration of anti-tumor T cells into tumors. Currently, YH003 is undergoing phase II multi-regional clinical trials (MRCTs) for the treatment of patients with unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC). About YH001 YH001 is an anti-CTLA-4 monoclonal antibody. CTLA-4 is a key target for tumor immunotherapies, due to the potential to enhance the immune response to tumor cells and promote removal of regulatory T cells from the tumor microenvironment. Blocking the inhibitory signals from both CTLA-4 and PD-1 to enhance the anti-tumor responses is considered a promising tumor immunotherapy, as they control different types of T cells. Currently, YH001 is undergoing phase II MRCTs for the treatment of patients with advanced non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Moreover, Biocytogen/Eucure Biopharma has entered into a collaborative partnership agreement with TRACON Pharmaceuticals (NASDAQ: TCON) for the development of YH001 for multiple oncology indications, including soft tissue sarcoma, in North America. About Eucure Biopharma As a wholly owned subsidiary of Biocytogen, Eucure Biopharma undertakes the mission of clinical development for Biocytogen’s R&D pipelines. Relying on a strong clinical development team and extensive clinical development experience, Eucure Biopharma focuses on antibody drug therapy for oncology and other indications. The company has established a product pipeline for more than 10 targets, with two products in phase II MRCT and two in phase I. For more information, please visit www.eucure.com. About Biocytogen Biocytogen Pharmaceuticals (Beijing) Co., Ltd. is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMabTM /RenLite® mouse platforms for fully human monoclonal and bispecific antibody development, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop antibody drugs for more than 1000 targets, known as Project Integrum, and has entered ongoing collaborations with dozens of partners worldwide to produce a variety of first-in-class and/or best-in-class antibody drugs. The company's pipeline includes 12 core products, among which two products are in phase II MRCTs and two products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. For more information, please visit www.biocytogen.com. Biocytogen/Eucure Biopharma Contacts: Antibody assets: Vivian Tian, PhD bd@eucure.com +86 010-56967680 Media: Zimeng Zhang, PhD pr@bbctg.com.cn +86 010-56967680
2022.05.24
ニュース & ウェビナー
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29
Apr , 2022
Biocytogen Enters into Antibody Agreement with Merck
BEIJING, CHINA, April 29, 2022 – Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (Biocytogen) announced that it has entered into an evaluation and option agreement with Merck to grant them a sole license to evaluate Biocytogen’s proprietary antibodies against at least three distinct targets with an option to acquire some of the assets at a later date for therapeutic product development for all uses worldwide. Under the agreement, Biocytogen will provide Merck antibodies directed against at least three targets specified by them from Biocytogen’s Project Integrum (also called HiTS Platform), which are generated by leveraging Biocytogen’s proprietary RenMiceTM Platform. Merck will carry out feasibility tests and be responsible for further development and commercialization of the products if exercising an option. Additional targets subject to mutual discretion may be included under this agreement. Dr. Yuelei Shen, President and CEO of Biocytogen, said: “Thanks to Merck’s recognition of our proprietary platform and antibody discovery capabilities, we believe that differentiated candidates generated from our innovative models and discovery platform can quickly advance novel antibody-based therapeutics. Our RenMiceTM-based Project Integrum aims to discover antibodies against more than 1,000 targets. We welcome collaboration with partners worldwide to realize the full potential of this platform.” About Biocytogen Biocytogen Pharmaceuticals (Beijing) Co., Ltd. is a global biotech company that drives the research and development of new drugs with innovative technologies. The company is committed to becoming a global headstream of new drugs to bring benefits to patients worldwide. Based on the fully human antibody RenMabTM and RenLiteTM mice for fully human antibody production with robust humoral responses, highly diverse antibody repertoires and superior affinity, Biocytogen has integrated its platforms in monoclonal and bispecific antibody development platforms, in vivo drug efficacy screening platforms and strong clinical development ability to streamline the entire drug development process. Biocytogen has launched Project Integrum, the world’s first large-scale antibody discovery screening program adopting an evidence-based in vivo efficacy screening methodology to concurrently generate and screen antibodies against over 1,000 potential druggable targets, most of which have not been explored in clinical trials yet. With the implementation of Project Integrum, Biocytogen has entered ongoing collaborations with dozens of partners worldwide to produce many first-in-class and/or best-in-class antibody drugs. Biocytogen’s pipeline includes 12 core products among which 2 products are in phase II multi-regional clinical trials (MRCTs) and 2 products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. About Merck Merck, a leading science and technology company, operates across healthcare, life science and electronics. Around 60,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From advancing gene editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2021, Merck generated sales of € 19.7 billion in 66 countries.Scientific exploration and responsible entrepreneurship have been key to Merck’s technological and scientific advances. This is how Merck has thrived since its founding in 1668. The founding family remains the majority owner of the publicly listed company. Merck holds the global rights to the Merck name and brand. The only exceptions are the United States and Canada, where the business sectors of Merck operate as EMD Serono in healthcare, MilliporeSigma in life science, and EMD Electronics.
07
Apr , 2022
Biocytogen Subsidiary Eucure Biopharma Completes First Patient Dosing for Phase I Clinical Trial of YH003 (Anti-CD40 mAb) Triple Combination Therapy
BEIJING, April 7, 2022 - Biocytogen subsidiary Eucure Biopharma announced the first patient dosing for a phase I clinical trial (No. YH003005) of YH003 (anti-CD40 monoclonal antibody, mAb) in combination with YH001 (anti-CTLA-4 mAb) and pembrolizumab (anti-PD-1 mAb)  in Australia. The study is an open-label, dose-escalation study designed to evaluate the safety, tolerability and efficacy of YH003 in combination with YH001 and pembrolizumab in patients with advanced solid tumors. Pharmacokinetics and immunogenicity of YH003 will also be evaluated. “Previous phase I clinical trials of YH003/Toripalimab (anti-PD-1 mAb) combination therapy and YH001/Toripalimab combination therapy indicate desirable safety profiles and preliminary efficacy for both products,” said Dr. Yuelei Shen, Chairman and CEO of Biocytogen and Eucure Biopharma. “The combination of CTLA-4, PD-1 and CD40 mAbs is based on their different but complementary biological mechanisms; we hope that the three-drug combination study can further strengthen the antitumor efficacy to benefit patients.” About YH003 YH003 is a humanized IgG2 agonistic CD40 antibody. Whether used as a single agent or in combination with anti-PD-1 mAb drugs, YH003 demonstrated strong anti-tumor effects against multiple tumor models in Biocytogen’s humanized CD40 mice, without exhibiting hepatotoxicity or other toxicities. Pharmacodynamic studies in mice indicate that YH003 significantly increased the infiltration of anti-tumor T cells into tumors. About YH001 YH001 is an anti-CTLA-4 monoclonal antibody. CTLA-4 is a key target for tumor immunotherapies, due to the potential to enhance the immune response to tumor cells and promote removal of regulatory T cells (Treg) from the tumor microenvironment. Blocking the inhibitory signals from both CTLA-4 and PD-1 to enhance the anti-tumor responses is considered a promising tumor immunotherapy, as they control the different types of T cells. About Eucure Biopharma As a wholly owned subsidiary of Biocytogen, Eucure Biopharma undertakes the mission of clinical development for Biocytogen’s R&D pipelines. Relying on a strong clinical development team and extensive clinical development experience, Eucure Biopharma focuses on antibody drug therapy for oncology and other indications. The company has established a product pipeline for more than 10 targets, with two products in launched phase II MRCT and two in phase I. About Biocytogen Biocytogen Pharmaceuticals (Beijing) Co., Ltd. is a global biotech company that streamlines the research and development of antibody drugs using innovative technologies, including  RenMabTM and RenLiteTM mice for fully human antibody production, high-throughput antibody screening platforms, in vivo drug efficacy screening capabilities and strong clinical development ability. Biocytogen is undertaking a large-scale project to develop antibody drugs in collaboration with global partners for more than 1000 druggable targets, known as Project Integrum. With the implementation of Project Integrum, Biocytogen has entered ongoing collaborations with dozens of partners worldwide and has established a pipeline of 12 core products, with 2 products in phase II MRCT and 2 products in phase I trials. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany.
24
May , 2022
Biocytogen/Eucure Biopharma to Present Clinical Data from YH003 (anti-CD40 mAb) and YH001 (anti-CTLA-4 mAb) Trials at 2022 American Society of Clinical Oncology (ASCO) Annual Meeting
Beijing, China, May 24, 2022 /PRNewswire/ -- Eucure Biopharma, a wholly owned subsidiary of Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen"), today announced that it will present two posters at the 2022 ASCO Annual Meeting, taking place in Chicago, IL and virtually from June 3-7, 2022. The posters describe updates from two phase I clinical studies in Australia for internally developed monoclonal antibodies (mAbs) YH003 (anti-CD40, abstract # 2603) and YH001 (anti-CTLA-4, abstract # 2602). Both YH003 and YH001 demonstrate favorable safety and tolerability profiles and preliminary efficacy when administered in combination with anti-PD-1 mAb to patients with advanced solid tumors. The details of the presentations are as follows: Title: A phase I open-label, dose escalation of YH003, an anti-CD40 monoclonal antibody, in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors. Corresponding author: Dr. Jermaine Coward Trial: NCT04481009 Abstract number: 2603 Session: Poster Session 3: Developmental Therapeutics—Immunotherapy Title: A first-in-human phase I dose escalation of YH001, an anti-CTLA-4 monoclonal antibody (mAb), in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors. Corresponding author: Dr. Vinod Ganju Trial: NCT04357756 Abstract number: 2602 Session: Poster Session 3: Developmental Therapeutics—Immunotherapy Both posters will be presented in-person on Sunday, June 5 from 8:00 AM–11:00 AM CT. About YH003 YH003 is a humanized IgG2 agonistic CD40 antibody. Whether used as a single agent or in combination with anti-PD-1 mAb drugs, YH003 demonstrated strong anti-tumor effects against multiple tumor models in Biocytogen’s humanized CD40 mice, without exhibiting hepatotoxicity or other toxicities. Pharmacodynamic studies in mice indicate that YH003 significantly increased the infiltration of anti-tumor T cells into tumors. Currently, YH003 is undergoing phase II multi-regional clinical trials (MRCTs) for the treatment of patients with unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC). About YH001 YH001 is an anti-CTLA-4 monoclonal antibody. CTLA-4 is a key target for tumor immunotherapies, due to the potential to enhance the immune response to tumor cells and promote removal of regulatory T cells from the tumor microenvironment. Blocking the inhibitory signals from both CTLA-4 and PD-1 to enhance the anti-tumor responses is considered a promising tumor immunotherapy, as they control different types of T cells. Currently, YH001 is undergoing phase II MRCTs for the treatment of patients with advanced non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Moreover, Biocytogen/Eucure Biopharma has entered into a collaborative partnership agreement with TRACON Pharmaceuticals (NASDAQ: TCON) for the development of YH001 for multiple oncology indications, including soft tissue sarcoma, in North America. About Eucure Biopharma As a wholly owned subsidiary of Biocytogen, Eucure Biopharma undertakes the mission of clinical development for Biocytogen’s R&D pipelines. Relying on a strong clinical development team and extensive clinical development experience, Eucure Biopharma focuses on antibody drug therapy for oncology and other indications. The company has established a product pipeline for more than 10 targets, with two products in phase II MRCT and two in phase I. For more information, please visit www.eucure.com. About Biocytogen Biocytogen Pharmaceuticals (Beijing) Co., Ltd. is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMabTM /RenLite® mouse platforms for fully human monoclonal and bispecific antibody development, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop antibody drugs for more than 1000 targets, known as Project Integrum, and has entered ongoing collaborations with dozens of partners worldwide to produce a variety of first-in-class and/or best-in-class antibody drugs. The company's pipeline includes 12 core products, among which two products are in phase II MRCTs and two products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. For more information, please visit www.biocytogen.com. Biocytogen/Eucure Biopharma Contacts: Antibody assets: Vivian Tian, PhD bd@eucure.com +86 010-56967680 Media: Zimeng Zhang, PhD pr@bbctg.com.cn +86 010-56967680