RenLite：fully human bispecific antibody (BsAb) platform
RenLite mice have full human antibody heavy chain variable regions and a common light chain human variable region for the discovery of fully human bispecific antibodies.
RenLite mouse was generated by size unlimited chromosome engineering technology SUPCE.
RenLite mouse has diversified heavy chain repertoire similar to that of humans.
RenLite-derived common light chain antibodies are easy to assemble into BsAb with low mismatch rate and ideal physiochemical properties.
RenLite mice can generate robust immune response comparable to wild type mice.
RenLite-derived antibodies have high binding affinity at sub-nanomolar range.
Advancing Bispecific Antibody Discovery using a Common Light Chain Immunoglobulin Humanized Mouse