RenLite：fully human bispecific antibody (BsAb) platform

RenLite mice have full human antibody heavy chain variable regions and a common light chain human variable region for the discovery of fully human bispecific antibodies.

• RenLite mouse was generated by size unlimited chromosome engineering technology SUPCE.

 

• RenLite mouse has diversified heavy chain repertoire similar to that of humans.
• RenLite-derived common light chain antibodies are easy to assemble into BsAb with low mismatch rate and ideal physiochemical properties.

• RenLite mice can generate robust immune response comparable to wild type mice.
• RenLite-derived antibodies have high binding affinity at sub-nanomolar range.

Posters

Advancing Bispecific Antibody Discovery using a Common Light Chain Immunoglobulin Humanized Mouse