B-hCD48 mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-hCD48 mice

Strain Name	C57BL/6-Cd48^{tm1(CD48)Bcgen}/Bcgen	Common Name	B-hCD48 mice
Background	C57BL/6	Catalog number	111141
Aliases	CD48: BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102

Protein expression analysis of CD48 in T cells, CD4+T cells and CD8+T cells of splenocytes

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Strain specific CD48 expression analysis in homozygous B-hCD48 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD48 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD48 antibody. Mouse CD48 was detectable in T cells (A), CD4+T cells (B) and CD8+T cells (C) of wild-type C57BL/6 mice. Human CD48 was exclusively detectable in T cells (A), CD4+T cells (B) and CD8+T cells (C) of homozygous B-hCD48 mice but not in wild-type C57BL/6 mice.

Protein expression analysis of CD48 in NK cells, B cells and dendritic cells of splenocytes

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Strain specific CD48 expression analysis in homozygous B-hCD48 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD48 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD48 antibody. Mouse CD48 was detectable in NK cells (A), B cells (B) and dendritic cells (C) of wild-type C57BL/6 mice. Human CD48 was exclusively detectable in NK cells (A), B cells (B) and dendritic cells (C) of homozygous B-hCD48 mice but not in wild-type C57BL/6 mice.

Protein expression analysis of CD48 in monocytes, macrophages and granulocytes of splenocytes

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Strain specific CD48 expression analysis in homozygous B-hCD48 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD48 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD48 antibody. Mouse CD48 was detectable in monocytes (A), macrophages (B) and granulocytes (C) of wild-type C57BL/6 mice. Human CD48 was exclusively detectable in monocytes (A), macrophages (B) and granulocytes (C) of homozygous B-hCD48 mice but not in wild-type C57BL/6 mice.

Protein expression analysis of CD48 in T cells, CD4+T cells and CD8+T cells of lymph nodes

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Strain specific CD48 expression analysis in homozygous B-hCD48 mice by flow cytometry. Lymph nodes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD48 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD48 antibody. Mouse CD48 was detectable in T cells (A), CD4+T cells (B) and CD8+T cells (C) of wild-type C57BL/6 mice. Human CD48 was exclusively detectable in T cells (A), CD4+T cells (B) and CD8+T cells (C) of homozygous B-hCD48 mice but not in wild-type C57BL/6 mice.

Protein expression analysis of CD48 in NK cells and B cells of lymph nodes

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Strain specific CD48 expression analysis in homozygous B-hCD48 mice by flow cytometry. Lymph nodes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD48 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD48 antibody. Mouse CD48 was detectable in NK cells (A) and B cells (B) of wild-type C57BL/6 mice. Human CD48 was exclusively detectable in NK cells (A) and B cells (B) of homozygous B-hCD48 mice but not in wild-type C57BL/6 mice.