B-hCD3E/h4-1BB mice(C)_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-hCD3E/h4-1BB mice(C)

Strain Name	BALB/cCrSlcNifdc-Cd3e^{tm1(CD3E)Bcgen}Tnfrsf9^{tm1(TNFRSF9)Bcgen}/Bcgen	Common Name	B-hCD3E/h4-1BB mice(C)
Background	BALB/cCrSIcNifdc	Catalog number	112903
Related Genes	CD3E, IMD18, T3E, TCRE,CD3e molecule; ILA,4-1BB,CD137,CDw137,MD109
NCBI Gene ID	21942

Protein expression analysis in spleen

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Strain specific CD3E expression analysis in wild-type BALB/c mice and homozygous humanized B-hCD3E/h4-1BB mice(C) by flow cytometry. Splenocytes were collected from wild-type BALB/c mice (+/+) and homozygous B-hCD3E/h4-1BB mice(C) (H/H; H/H), and analyzed by flow cytometry. Mouse CD3E was only detectable in wild-type BALB/c mice. Human CD3E was exclusively detectable in homozygous B-hCD3E/h4-1BB mice(C), but not in wild-type BALB/c mice.

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Strain specific 4-1BB expression analysis in wild-type BALB/c mice and homozygous humanized B-hCD3E/h4-1BB mice(C) by flow cytometry. Splenocytes were collected from wild-type BALB/c mice (+/+) and homozygous B-hCD3E/h4-1BB mice(C) (H/H; H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry. Mouse 4-1BB was only detectable in wild-type BALB/c mice. Human h4-1BB was exclusively detectable in homozygous B-hCD3E/h4-1BB mice(C), but not in wild-type BALB/c mice.