B-hF11R mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Cytokine Humanized Mice

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B-hF11R mice

Strain Name	C57BL/6N-F11r^{tm1(F11R)Bcgen}/Bcgen	Common Name	B-hF11R mice
Background	C57BL/6N	Catalog number	112164
Aliases	F11R, JAM, JAM1, JAMA, JCAM, KAT, PAM-1

Protein expression analysis of F11R(JAM1) in platelet

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Strain specific F11R expression analysis in homozygous B-hF11R mice by flow cytometry. Platelet were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hF11R mice (H/H), and analyzed by flow cytometry with species-specific anti-F11R antibody. Mouse F11R was detectable in platelet of wild-type C57BL/6 mice. Human F11R was exclusively detectable in platelet of homozygous B-hF11R mice but not in wild-type C57BL/6 mice.

Protein expression analysis of F11R(JAM1) in T cells, B cells and Monocytes of splenocytes

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Strain specific F11R expression analysis in homozygous B-hF11R mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hF11R mice (H/H), and analyzed by flow cytometry with species-specific anti-F11R antibody. Mouse F11R was not detectable in T cells (A), B cells (B) and monocytes (C) of wild-type C57BL/6 mice. Human F11R was not detectable in T cells (A), B cells (B) and was detectable monocytes (C) of homozygous B-hF11R mice.

Protein expression analysis of F11R(JAM1) in NK cells, dendritic cells and Macrophages of splenocytes

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Strain specific F11R expression analysis in homozygous B-hF11R mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hF11R mice (H/H), and analyzed by flow cytometry with species-specific anti-F11R antibody. Mouse F11R was detectable in NK cells (A), dendritic cells (B) and macrophages (C) of wild-type C57BL/6 mice. Human F11R was exclusively detectable in NK cells (A), dendritic cells (B) and macrophages (C) of homozygous B-hF11R mice but not in wild-type C57BL/6 mice.

Protein expression analysis of F11R(JAM1) in Stem cells of bone marrow

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Strain specific F11R expression analysis in homozygous B-hF11R mice by flow cytometry. Bone marrow were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hF11R mice (H/H), and analyzed by flow cytometry with species-specific anti-F11R antibody. Mouse F11R was detectable in stem cells of wild-type C57BL/6 mice. Human F11R was exclusively detectable in stem cells of homozygous B-hF11R mice but not in wild-type C57BL/6 mice.

Protein expression analysis of F11R(JAM1) in Endothelial cells of lung

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Strain specific F11R expression analysis in homozygous B-hF11R mice by flow cytometry. Lung were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hF11R mice (H/H), and analyzed by flow cytometry with species-specific anti-F11R antibody. Mouse F11R was detectable in endothelial cells of wild-type C57BL/6 mice. Human F11R was exclusively detectable in endothelial cells of homozygous B-hF11R mice but not in wild-type C57BL/6 mice.