B-hCFB mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Cytokine Humanized Mice

Text

B-hCFB mice

Strain Name

C57BL/6-Cfb^{tm1(CFB)Bcgen}/Bcgen

Common Name

B-hCFB mice

Background

C57BL/6N

Catalog number

111006

Aliases

CFB: BF, FB, BFD, GBG, CFAB, CFBD,

PBF2, AHUS4, FBI12, H2-Bf, ARMD14

Protein expression analysis

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Strain specific hCFB expression analysis in homozygous B-hCFB mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCFB mice (H/H), and analyzed by ELISA with species-specific CFB ELISA kit. Human CFB was exclusively detectable in homozygous B-hCFB mice but not in wild-type mice.

mRNA expression analysis

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Strain specific analysis of CFB gene expression in wild-type mice and B-hCFB mice by RT-PCR. Mouse Cfb mRNA was detectable in liver of wild-type mice. Human CFB mRNA was detectable only in homozygous B-hCFB but not in wild-type mice.