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B-Col10a1-iCre mice
Strain Name


C57BL/6-Col10a1tm1(icre)Bcgen/Bcgen


Stock No. 


110122


Common name


B-Col10a1-iCre mice


Gene symbol and name 


Col10a1 collagen, type X, alpha 1


Strain of origin

C57BL/6

Chromosome  10
Coat color Black Dietary information

Growth and reproduction diet for experimental mice

Results of agarose gel electrophoresis

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Gel image of PCR products. PCR products are separated by gel electrophoresis on a 2% agarose gel. PC: samples used for PCR were collected from heterozygous mice; WT: samples used for PCR were collected from wild type mice; H2O: blank control.


Phenotype Analysis


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Col10-Cre-marked cells, which excluded periosteal cells, gave rise to ~58%of all Lepr+ BMSCs.

(C) Confocal imaging of femur sections from Col10cre; R26tdTomato mice at P3 showed that Col10-Cre (Col10-Cre was purchased from Biocytogen Co. Ltd., Beijing, China) marked cells included chondrocytes, but not periosteal cells. Asterisks indicated the periosteum. (n=3 mice from 3 independent experiments)

(D and E) Confocal imaging (D) and flow cytometry (E) showed that Col10-Cre marked cells gave rise to most of the Lepr+ BMSCs at 6 months of age. (n = 3 mice from 3 independent experiments)

 (source: Hui Sophie Shu, et al., 2021)