Strain specific CD98 expression analysis in homozygous B-hCD98/Rag2 KO mice by flow cytometry. Brain were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody after trypsin digestion. Mouse CD98 was detectable in WT mice (+/+). Human CD98 was exclusively detectable in homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-) but not in WT mice (+/+).

Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+) and human CD98 was not detectable in WT mice (+/+). There were no T cells in homozygous B-hCD98HC/Rag2 KO mice.

Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+) and human CD98 was not detectable in WT mice (+/+). There were no B cells in homozygous B-hCD98HC/Rag2 KO mice.

Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+). Human CD98 was exclusively detectable in homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-) but not in WT mice (+/+).