B-hTNFRSF11A mice
| Strain Name |
C57BL/6N-Tnfrsf11atm1(TNFRSF11A)Bcgen/Bcgen
|
Common Name | B-hTNFRSF11A mice |
| Background | C57BL/6N | Catalog number | 112784 |
|
Aliases |
CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCE-R, TRANCER |
||
Description
- RANKL binds to TNFRSF11A and induces the differentiation of osteoclast precursors into osteoclasts, promoting the activation of osteoclasts.
- B-hTNFRSF11A mice used for myeloma and osteoporosis.
Protein expression analysis
Western blot analysis of TNFRSF11A protein expression in homozygous B-hTNFRSF11A mice. Various tissue lysates were collected from wild-type C57BL/6N mice (+/+) and homozygous B-hTNFRSF11A mice (H/H), and then analyzed by western blot with anti-TNFRSF11A antibody (abcam, ab182158). 40 μg total proteins were loaded for western blotting analysis. TNFRSF11A was detected in liver and stomach.
Strain specific analysis of TNFRSF11A mRNA expression in wild-type C57BL/6 mice and B-hTNFRSF11A mice by RT-PCR. Liver RNA were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hTNFRSF11A mice (H/H). Mouse Tnfrsf11a mRNA was detectable only in wild-type C57BL/6 mice. Human TNFRSF11A mRNA was detectable only in homozygous B-hTNFRSF11A mice but not in wild-type mice.
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