B-hNKC mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Other humanized mice

Text

B-hNKC mice

Strain Name	C57BL/6-Klrb1a^tm1Bcgen Clec2h^tm1Bcgen Klrb1^{tm1(KLRB1)Bcgen} Klrb1c^tm1Bcgen Klrb1b^tm1Bcgen Clec2i^tm1Bcgen Clec2g^tm1Bcgen Clec2f^tm1Bcgen Klrb1f^tm1Bcgen Clec2e^tm1Bcgen Clec2d^{tm1(CLEC2D)Bcgen} Cd69^{tm1(CD69)Bcgen} NKC^{tm1(KLRF1)Bcgen} NKC^{tm1(CLEC2B)Bcgen} NKC^{tm1(KLRF2)Bcgen} NKC^{tm1(CLEC2A)Bcgen} Clec2m^tm1Bcgen Clec12a^{tm1(CLEC12A)Bcgen} Clec1b^{tm1(CLEC1B)Bcgen} Clec12b^{tm1(CLEC12B)Bcgen} Clec9a^{tm1(CLEC9A)Bcgen}Clec1a^{tm1(CLEC1A)Bcgen} Clec7a^{tm1(CLEC7A)Bcgen} Olr1^{tm1(OLR1)Bcgen}Tmem52b^{tm1(TMEM52B)Bcgen} Gabarapl1^{tm1(GABARAPL1)Bcgen} Klre1^tm1Bcgen Cd94^{tm1(CD94)Bcgen} Klrk1^{tm1(KLRK1)Bcgen} NKC^{tm1(KLRC4)Bcgen} Klrc3^{tm1(KLRC3)Bcgen} Klrc2^{tm1(KLRC2)Bcgen} Klrc1^{tm1(KLRC1)Bcgen} /Bcgen	Common Name	B-hNKC mice
Background	C57BL/6	Catalog number	114042
Related Genes	NA
NCBI Gene ID	NA

Targeting strategy

Gene targeting strategy for B-hNKC mice. The mouse NKC cluster is replaced by human NKC cluster counterparts in B-hNKC mice. The human NKC expression is driven by endogenous human NKC promoter, 5’UTR and 3’UTR. While mouse NKC gene transcription and translation will be disrupted. The mouse NKC cluster contain Klrb1a, Clec2h, Klrb1, Klrb1c, Klrb1b, Clec2i, Clec2g, Clec2f, Klrb1f, Clec2e, Clec2d, Cd69, Clec2m, Clec12a, Clec1b, Clec12b, Clec9a, Clec1a, Clec7a, Olr1, Tmem52b, Gabarapl1, Klre1, Klrd1, Klrk1, Klrc3, Klrc2 and Klrc1. The human NKC cluster contain KLRB1, CLEC2D, CD69, KLRF1, CLEC2B, KLRF2, CLEC2A, CLEC12A, CLEC1B, CLEC12B, CLEC9A, CLEC1A, CLEC7A, OLR1, TMEM52B, GABARAPL1, KLRD1, KLRK1, KLRC4, KLRC3, KLRC2 and KLRC1.