B-hNKP46 mice(C)_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-hNKP46 mice(C)

Strain Name	BALB/cCrSlcNifdc-Ncr1^{tm1(NCR1)Bcgen}/Bcgen	Common Name	B-hNKP46 mice(C)
Background	BALB/cCrSlcNifdc	Catalog number	112004
Aliases	CD335, LY94, NK-p46, NKP46

Protein expression analysis

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Strain specific NKP46 expression analysis in wild-type and B-hNKP46 mice(C) by flow cytometry. Splenocytes were collected from BALB/c (+/+) and homozygous B-hNKP46 mice(C) (H/H), and analyzed by flow cytometry with species-specific NKP46 antibody. Mouse NKP46 was detectable in wild-type mice. Human NKP46 was exclusively detectable in homozygous B-hNKP46 mice(C).

Protein expression analysis in T and B cells of spleen

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Strain specific NKP46 expression analysis in wild-type and B-hNKP46 mice(C) by flow cytometry. Splenocytes were collected from BALB/c (+/+) and homozygous B-hNKP46 mice(C) (H/H), and analyzed by flow cytometry with species-specific NKP46 antibody. Mouse NKP46 was not detectable in T and B cells of wild-type mice. Human NKP46 was not detectable in T and B cells of homozygous B-hNKP46 mice(C).

Protein expression analysis in blood

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Strain specific NKP46 expression analysis in wild-type and B-hNKP46 mice(C) by flow cytometry. Blood cells were collected from BALB/c (+/+) and homozygous B-hNKP46 mice(C) (H/H), and analyzed by flow cytometry with species-specific NKP46 antibody. Mouse NKP46 was detectable in wild-type mice. Human NKP46 was exclusively detectable in homozygous B-hNKP46 mice(C).

Protein expression analysis in T and B cells of blood

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Strain specific NKP46 expression analysis in wild-type and B-hNKP46 mice(C) by flow cytometry. Blood cells were collected from BALB/c (+/+) and homozygous B-hNKP46 mice(C) (H/H), and analyzed by flow cytometry with species-specific NKP46 antibody. Mouse NKP46 was not detectable in T and B cells of wild-type mice. Human NKP46 was not detectable in T and B cells of homozygous B-hNKP46 mice(C).