B-hCD40/hFcRn mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-hCD40/hFcRn mice

Strain Name	C57BL/6-Cd40^{tm1(CD40)Bcgen} Fcgrt^{tm1(FCGRT)Bcgen}/Bcgen	Common Name	B-hCD40/hFcRn mice
Background	C57BL/6	Catalog number	111912
Related Genes	CD40 (Bp50, CDW40, TNFRSF5, p50) FCGRT (FCRN, FcgammaRn, alpha-chain)

Protein expression analysis

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Strain specific analysis of CD40 expression in homozygous B-hCD40/hFcRn mice by flow cytometry. Splenocytes were collected from C57BL/6 mice (+/+;+/+) and homozygous B-hCD40/hFcRn mice (H/H;H/H), and analyzed by flow cytometry with species-specific anti-CD40 antibody. Mouse CD40 was detectable in wild-type mice. Human CD40 was exclusively detectable in homozygous B-hCD40/hFcRn mice but not in wild-type mice.

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Strain specific analysis of FcRn expression in homozygous B-hCD40/hFcRn mice by western blot.Liver was collected from C57BL/6 mice (+/+;+/+) and homozygous B-hCD40/hFcRn mice (H/H;H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in wild-type mice. Human FcRn was detectable only in homozygous B-hCD40/hFcRn mice but not in wild-type mice.