B-Tg(hSIGLEC7/hSIGLEC9) mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-Tg(hSIGLEC7/hSIGLEC9) mice

Strain Name	C57BL/6N-Tg(CH17-302I14)1Bcgen/Bcgen	Common Name	B-Tg(hSIGLEC7/hSIGLEC9) mice
Background	C57BL/6N	Catalog number	121189
Aliases	SIGLEC7 (p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1) SIGLEC9 (CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE)

Protein expression analysis（F1）

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Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-type C57BL/6 mice mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were exclusively detectable in B-Tg(hSiglec7/hSiglec9) mice in NK cells.

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Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-typeC57BL/6 mice mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were exclusively detectable in B-Tg(hSiglec7/hSiglec9) mice in granulocytes.

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Protein expression analysis（F2）

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Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-typeC57BL/6 mice mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were exclusively detectable in B-Tg(hSiglec7/hSiglec9) mice in granulocytes.

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Protein expression analysis（F3）

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Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-type C57BL/6 mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were exclusively detectable in B-Tg(hSiglec7/hSiglec9) mice in NK cells.

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Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-type C57BL/6 mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were weakly detectable in B-Tg(hSiglec7-hSiglec9) mice in T cells.

Strain specific Siglec7 and Siglec9 expression analysis in B-Tg(hSiglec7/hSiglec9) mice by flow cytometry. Blood was collected from wild-type C57BL/6 mice (+/+) and B-Tg(hSiglec7/hSiglec9) mice, and analyzed by flow cytometry with species-specific anti-hSiglec-7 antibody and anti-hSiglec-9 antibody. Human Siglec-7 and Siglec-9 were weakly detectable in B-Tg(hSiglec7-hSiglec9) mice in B cells.