Functional analysis in APAP-induced liver damage in male B-hIL11/hIL11RA mice.(A) Schematic showing the process of APAP-induced liver damage in B-hIL11/hIL11RA mice. B-hIL11/hIL11RA mice (male, 8 weeks, n=5) were fasted overnight and inducted with APAP(400 mg/kg) for 24 h. Liver tissue were collected for functional analysis. (B) Representative IHC images of liver (200 X). (C) Quantification of ERK and p-ERK positive cells from hepatocytes.The IHC results showed that p-ERK increased significantly after APAP induction, and the increase degree was similar to that of wild mice. Values are expressed as mean ± SD. *p<0.05.