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B-Ldlr KO rats
Strain Name
SD-Ldlrtm1Bcgen/Bcgen 
Common Name  B-Ldlr KO rats
Background SD Catalog number 210506
Aliases  FH, FHC, FHCL1, LDLCQ2

Strain description



The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout rat a good model for studying atherosclerosis, familial hypercholesterolemia. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, metabolism research etc.



Targeting strategy

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Model validation and analysis


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Homozygous Ldlrtm1/Bcgen rats demonstrate significantly elevated serum cholesterol levels at 4 months of age.