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B-FcRn KO mice
Strain Name
C57BL/6N-Fcgrttm1Bcgen/Bcgen
Common Name  B-FcRn KO mice
Background C57BL/6N Catalog number  110165
Related Genes 
FCGRT(Fc fragment of IgG receptor and transporter)
NCBI Gene ID
14132

mRNA expression analysis 

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Strain specific analysis of Fcgrt gene expression in C57BL/6(+/+)  and B-FcRn KO mice by RT-PCR.

Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse Fcgrt  mRNA was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.

Protein expression analysis 

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Strain specific analysis of FcRn expression in C57BL/6(+/+)  and the homozygous B-FcRn KO mice by western blot.
Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse FcRn was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.

FcRn-deficient mice have low serum IgG



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Sera from C57BL/6(+/+) mice and B-FcRn KO mice were analyzed by ELISA .