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B-MUP-uPA mice
Strain Name C57BL/6-Hipp1tm2(MUP-uPA)/Bcgen  Common Name  B-MUP-uPA mice
Background C57BL/6 Catalog number 112036
Aliases

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Mouse uPA mRNA expression analysis by RT-qPCR

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uPA expression analysis in B-MUP-uPA mice by RT-qPCR. Liver and kidney tissues were collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (H/+) (n=3, female, 9-week-old). Mouse uPA was specific expression in the liver of heterozygous B-MUP-uPA mice and the level was higher than that in the wild-type.

ALT and AST concentrations in serum 

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Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (H/+) (n=10, male, 10-week-old). Serum ALT and AST concentrations were normal in B-MUP-uPA mice at 3 weeks of age, but elevated and up to peek in 5 weeks. Indicating that occurs liver injury in B-MUP-uPA mice.