B-hCTLA4/hTIGIT mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Humanized Mouse Models

Immune-checkpoint Humanized Mice

Text

B-hCTLA4/hTIGIT mice

Strain Name	C57BL/6-Ctla4^{tm1(CTLA4)Bcgen} Tigit^{tm1(TIGIT)Bcgen}/Bcgen	Common Name	B-hCTLA4/hTIGIT mice
Background	C57BL/6	Catalog number	111860
Related Genes	CTLA4 (ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12) TIGIT (VSIG9, VSTM3, WUCAM)

Protein expression analysis

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Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4hTIGIT mice (H/H;H/H), and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4hTIGIT mice but not in wild-type mice.

Protein expression analysis

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Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4hTIGIT mice (H/H;H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4hTIGIT mice but not in wild-type mice.