資源&動向

Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress

Heat stroke has increased in frequency worldwide in recent years and continues to have a high morbidity and mortality. Identification of the mechanisms mediating heat stoke is important and necessary. Our preliminary study revealed heat stress (HS)-induce

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NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival

We have identified an epidermal cancer stem (ECS) cell population that drives formation of rapidly growing and highly invasive and vascularized tumors. VEGF-A and neuropilin-1 (NRP-1) are highly expressed in ECS cell tumors and VEGF-A/NRP-1 interaction is

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Discovery of the oncogenic parp1, a target of bcr-abl and a potential therapeutics, in identification of mir-181a/PPFIA1 signaling pathway

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CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy

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Novel CTLA-4 Antibodies of Potent Antitumor Activity Were Verified in Humanized Mouse Models

CTLA-4 is a member of the immunoglobulin superfamily, and is homologous to the co-stimulatory protein CD28, and both receptors bind to the same ligands, CD80(B7-1) and CD86(B7-2).

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Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts

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Evaluating Anti-PD-1/CD40 In Vivo Efficacy and Safety on Humanized Double Knock-in Mice

Over the past years, monoclonal antibodies have been successfully utilized in clinical trials to block or active key mediators of immune checkpoint pathways. However, along the IO drug development process,

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Crizotinib enhances anti-CD30-LDM induced antitumor efficacy in NPM-ALK positive anaplastic large cell lymphoma

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KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility

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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development

4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells, dendritic cells, and activated endothelium.

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