||B-hTNFR2 MC38||Catalog number||310723|
|Aliases||CD120b, TBPII, TNFBR, TNFR80, TNFRSF1B||Disease||Colon carcinoma|
The mouse Tnfr2 gene was replaced by human TNFR2 coding sequence in B-hTNFR2 MC38 cells. Human TNFR2 is highly expressed on the surface of B-hTNFR2 MC38 cells.
Subcutaneous homograft tumor growth of B-hTNFR2 MC38 cells. B-hTNFR2 MC38 cells (5x105) and wild-type MC38 cells (5x105) were subcutaneously implanted into C57BL/6N mice (female, 6-9-week-old, n=5). Tumor volume and body weight were measured twice a week. (A) Average tumor volume ± SEM. (B) Body weight (Mean± SEM). Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hTNFR2 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.