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B-CAG-iCreERT2 mice
Strain Name



C57BL/6-Gt(ROSA)26Sortm1(CAG-icre/ERT2)/Bcgen


Stock No. 

110147

Common name


B-CAG-iCreERT2 mice


Gene symbol and name 

CAG promoter (a combination of artificially constructed promoter, which is composed of the early enhancer element of cytomegalovirus (CMV) and chicken beta-actin promoter)

Strain of origin

C57BL/6

Chromosome 

6

Coat color Black Dietary information

Growth and reproduction diet for experimental mice





Description


Homozygous mice for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. In this strain, Cre recombinase expression is under the control of CAG promoter. When crossed with a strain containing a loxP-site flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequence in the offspring.


Application


•Function research of genes

•Systemic knockout of lethal target genes in embryos


Phenotype analysis



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The genotype was B-CAG-iCreERT2(Mut/+)CAG-LSL-tdtomato(Mut/+) double-positive heterozygous mice were induced by Tamoxifen. The tdTomato red fluorescense protein signal was successfully detected in the tissue section experiment of the main tissues of the mice.