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B-hVSIG4 mice
Strain Name C57BL/6-Vsig4tm1(VSIG4)/Bcgen Common Name  B-hVSIG4 mice
Background C57BL/6N Catalog number  111035
Aliases 
CR, CRIg, Z39I, Z39IG

Gene description

Vsig4 (V-set and immunoglobulin domain containing 4) encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. It is expressed at high level in liver, dendritic cells, neutrophils, and resting macrophages but at low level in other organs including lung, heart, spleen, and lymph node while it is not expressed in T cells and B cells. This protein is a receptor for the complement component 3 fragments C3b and iC3b and inhibits of the alternative complement pathway convertases. It inhibits T cell proliferation, IL-2 production and Th cell–dependent humoral immune responses. This protein also promotes the differentiation of Foxp3+ regulatory (Treg) cells. VSIG4 has been studied in relation with an occurrence of autoimmune and/or inflammatory disorders, as it was shown that a soluble VSIG4-Fc fusion protein seems to protect against the development of experimental autoimmune arthritis[1], lupus nephritis, cutaneous disease[2] and hepatitis[3]. However, it is also recently reported that the expression of VSIG4 is related to the regulation of anti-tumour immunity such as development of lung cancer[4] and poor prognosis of high-grade glioma[5] or the like. Vsig4 is a target for drug development on cancer and autoimmune diseases. 

mRNA expression analysis

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Strain specific analysis of VSIG4 gene expression in wild-type C57BL/6 mice and homozygous B-hVSIG4 mice by RT-PCR. Mouse Vsig4 mRNA was detectable in liver tissue of wild-type C57BL/6 mice (+/+). Human VSIG4 mRNA was detectable only in homozygous B-hVSIG4 mice but not in wild-type mice.