|Strain Name||C57BL/6-Pvrigtm1(PVRIG)Tigittm1(TIGIT)/Bcgen||Common Name||B-hPVRIG/hTIGIT mice|
||CD112R; C7orf15CD112R; C7orf15;VSIG9, VSTM3, WUCAM|
NCBI Gene ID
mRNA expression analysis
Strain specific TIGIT expression analysis in homozygous B-hPVRIG/hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPVRIG/hTIGIT mice (H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-TIGIT antibody. Mouse TIGIT was detectable in wild-type mice. Human TIGIT was exclusively detectable in homozygous B-hPVRIG/hTIGIT mice but not in wild-type C57BL/6 mice.