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B-hCD45 mice
Strain Name

C57BL/6-Ptprctm1(PTPRC)/Bcgen

Common Name 

B-hCD45 mice

Background C57BL/6 Catalog number  

110973


Related Genes 

LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180


Gene description


CD45 (protein tyrosine phosphatase receptor type C, gene ID 5788) encodes a 180 - 240 kD single chain type I membrane glycoprotein, also known as leukocyte common antigen (LCA), protein tyrosine phosphatase, receptor type C (PTPRC) and T200, belongs to the protein tyrosine phosphatase (PTP) family. PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The protein may be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.


Protein expression analysis


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Strain specific CD45 expression analysis in heterozygous B-hCD45 mice by flow cytometry. Blood was collected from wild-type C57BL/6 (+/+) and heterozygous B-hCD45 mice (H/+) and analyzed by flow cytometry with species-specific anti-CD45 antibody. Mouse CD45 was detectable in wild-type mice and heterozygous B-hCD45 mice. Human CD45 was exclusively detectable in heterozygous B-hCD45 mice but not in wild-type mice.