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B-hCD4 mice
Strain Name C57BL/6-Cd4tm1(CD4)/Bcgen Common Name  B-hCD4 mice
Background C57BL/6 Catalog number  110842
Aliases 
CD4mut

Gene description


CD4 gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. 



Protein expression analysis


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Strain specific CD4 expression analysis in heterozygous B-hCD4 mice by flow cytometry. Thymocytes were collected from wild type C57BL/6 (+/+) and heterozygous B-hCD4 mice (H/+) and analyzed by flow cytometry with species-specific anti-CD4 antibody. Mouse CD4 was detectable in WT mice and heterozygous B-hCD4 mice. Human CD4 was exclusively detectable in heterozygous B-hCD4 mice but not in WT mice.