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B-hAMHR2 mice
Strain Name C57BL/6-Amhr2tm1(AMHR2)/Bcgen Common Name  B-hAMHR2 mice
Background C57BL/6 Catalog number   111143
Related Genes 
AMHR2, AMHR, MISR2, MISRII, MRII

Gene description

AMHR2 (Anti-Müllerian hormone receptor 2) is a receptor for anti-Müllerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. In women, AMH is expressed by the granulosa cells of the ovary, where it is responsible for regulation of various aspects of folliculogenesis. Diagnostically, serum AMH levels are now routinely used clinically as a marker for measuring ovarian reserve in females. AMHR2 is one of the most abundant cytokine receptors in neurons, yet the abundance of AMHR2 in neurons is two orders of magnitude less than in the gonads and Müllerian duct, and AMHR2 is also issue enhanced (adrenal gland, ovary, testis); not detected in human brain and immune cells. AMH most prominently signals using a combination of AMHR2 and ACVR1/BMPR1A/BMPR1B to phosphorylate and activate Smad 1/5/9 of the BMP pathway, and not Smad2/3 of the activin/TGFβ pathway.  AMHR2 is also expressed by ovarian, breast, and prostate cancers and these cancer cells have been reported to apoptose in response to exposure to the Müllerian inhibiting substance (MIS). Antibodies have been developed that specifically target MISIIR and may be useful as vehicles for drugs and toxins for targeted cancer therapy. 


Protein expression analysis 


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Strain specific analysis of AMHR2 expression in WT and B-hAMHR2 mice by western blot. Lung were collected from WT mice and homozygous B-hAMHR2 (H/H) mice. Mouse AMHR2 was detectable in WT mice. Human AMHR2 was exclusively detectable in homozygous B-hAMHR2. The antibody is cross-reactive between human and mouse.