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B-hTNFA mice
Strain Name
C57BL/6-Tnftm1(TNF)Bcgen/Bcgen
  Common Name  B-hTNFA mice
Background C57BL/6   Catalog number  110002
Related Genes 

TNF (tumor necrosis factor, TNF-α)

NCBI Gene ID
21926

Targeting strategy



Gene targeting strategy for B-hTNFA mice. The targeted mouse Tnf whole genomic sequence including 5'UTR, 3'UTR and coding region was replaced by human TNF whole genomic sequence in B-hTNFA mice. 


Protein expression analysis


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Strain specific TNFα expression analysis in homozygous B-hTNFA mice by ELISA

Serum were collected from WT and homozygous B-hTNFA (H/H) mice stimulated with LPS in vivo, and analyzed by ELISA with species-specific TNFα ELISA kit. Mouse TNFα was detectable in WT mice. Human TNFα was exclusively detectable in homozygous B-hTNFA but not WT mice.