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B-Apoe KO rats
Strain Name
SD-Apoetm1Bcgen/Bcgen 
Common Name  B-Apoe-KO rats
Background SD Catalog number 210508
Aliases  /
Project background

Apolipoprotein E (ApoE) is primarily produced by the liver and macrophages in the peripheral tissues, or by astrocytes and microglia in the central nervous system. ApoE transports lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into the blood, preventing the accumulation of cholesterol-rich particles in the plasma. The function of ApoE protein has been widely studied in cardiovascular disease, lipid metabolism, and Alzheimer’s diseases. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, atherosclerosis, metabolism research and Alzheimer’s diseases etc.


Targeting strategy

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Model validation and analysis


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Homozygous Apoetm1/Bcgen rat showed loss of ApoE protein in liver and spleen via western blots. 
Homozygous Apoetm1/Bcgen rat demonstrates significantly elevated serum cholesterol levels at the age of 2 months.